| Solution Information | help | |
| Enzyme: | Signal transducer and activator of transcription 1-alpha/beta | |
| inhibitor: | BDBM46419 | |
| substrate: | n/a | |
| Solution Type: | Aqueous | |
| pH at Preparation: | n/a | |
| Temp. Prep.: | n/a | |
| Comments: | Assay Overview: The purpose of this assay is to determine whether a subset of compounds identified as active in a previous set of experiments entitled, "Primary cell-based high throughput screening assay to measure STAT3 inhibition" (PubChem AID 862), and that confirmed activity in a set of experiments entitled, "Confirmation cell-based high throughput screening assay to measure STAT3 inhibition" (AID 1265), were nonselective inhibitors due to inhibition of STAT1. The compounds selected for testing in this AID met the following criteria: 1) they were declared active in AID 862 and AID 1265; 2) they were declared inactive in a set of experiments entitled, "Primary cell-based high throughput screening assay to measure STAT1 inhibition" (AID 920); 3) they were inactive in a set of experiments entitled, "Counterscreen assay for STAT3 inhibitors: cell-based high throughput assay to measure NF-kappaB inhibition" (AID 1308); and 4) they were inactive in a set of experiments entitled, "Cou | |
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